ExoticRx · exoticrx.com/drugs/ezogabine
US brand names:Potiga
Ezogabine is dosed at 2–5 mg/kg PO q8h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
First potassium channel opener anticonvulsant. Activates KCNQ2/3 (Kv7.2/7.3) potassium channels, stabilizing resting membrane potential and reducing neuronal excitability.
Retinal pigment changes and skin discoloration with chronic use. Urinary retention. Withdrawn from human market but available for veterinary investigational use. Limited data.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Controlled substance in the US
Controlled-drug status and schedules differ by country — check your local scheduling rules.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.