Cat · Felis catus · typical adult weight 2.50–7.00 kg
Imipenem-Cilastatin is dosed at 5–10 mg/kg IV q6-8h in cats, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.673 (2026-08-01). — Plumb's 10th ed (held) printed p.644, Imipenem/Cilastatin Sodium monograph spanning p.644-645; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Imipenem-Cilastatin is used in cats for Multi-drug resistant infections. Routes documented in cats: IV. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Imipenem-Cilastatin in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Primaxin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 5–10 mg/kg | q6-8h | 7-14 days | Multi-drug resistant infections | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.673 (2026-08-01). — Plumb's 10th ed (held) printed p.644, Imipenem/Cilastatin Sodium monograph spanning p.644-645; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 5 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.422 | • 5 mg/kg q6-8h IV, IM, or SQ. • 5 mg/kg q6-8h IV or IM, or q8h |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Binds penicillin-binding proteins, inhibiting cell wall synthesis. Ultra-broad spectrum including many resistant organisms. Cilastatin prevents renal metabolism of imipenem.
Reserve for multi-drug resistant infections. May lower seizure threshold. Nausea and vomiting with rapid IV infusion. Administer IV slowly over 20-30 minutes.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Imipenem-Cilastatin dose range in cats, with cited source references: IV 5–10 mg/kg q6-8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Imipenem-Cilastatin in cats: IV.
Cited course lengths for Imipenem-Cilastatin in cats include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Imipenem-Cilastatin is indicated in cats for: Multi-drug resistant infections.
These are general warnings for Imipenem-Cilastatin across species; consult the cat dosing table above for species-specific guidance. Reserve for multi-drug resistant infections. May lower seizure threshold. Nausea and vomiting with rapid IV infusion. Administer IV slowly over 20-30 minutes.
Why a species-specific page? Imipenem-Cilastatin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.