ExoticRx · exoticrx.com/drugs/imipenem-cilastatin
US brand names:Primaxin
Imipenem-Cilastatin is dosed at 5–10 mg/kg IV q6-8h in cats, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.673 (2026-08-01).. Verify against current literature before clinical use.
Binds penicillin-binding proteins, inhibiting cell wall synthesis. Ultra-broad spectrum including many resistant organisms. Cilastatin prevents renal metabolism of imipenem.
Reserve for multi-drug resistant infections. May lower seizure threshold. Nausea and vomiting with rapid IV infusion. Administer IV slowly over 20-30 minutes.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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