Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Imipenem-Cilastatin is dosed at 5–10 mg/kg IV q6-8h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.673 (2026-08-01).. Imipenem-Cilastatin is used in dogs for Multi-drug resistant infections. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Imipenem-Cilastatin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Primaxin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 5–10 mg/kg | q6-8h | 7-14 days | Multi-drug resistant infections | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.673 (2026-08-01). |
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Binds penicillin-binding proteins, inhibiting cell wall synthesis. Ultra-broad spectrum including many resistant organisms. Cilastatin prevents renal metabolism of imipenem.
Reserve for multi-drug resistant infections. May lower seizure threshold. Nausea and vomiting with rapid IV infusion. Administer IV slowly over 20-30 minutes.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Imipenem-Cilastatin dose range in dogs, with cited source references: IV 5–10 mg/kg q6-8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Imipenem-Cilastatin in dogs: IV.
Cited course lengths for Imipenem-Cilastatin in dogs include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Imipenem-Cilastatin is indicated in dogs for: Multi-drug resistant infections.
These are general warnings for Imipenem-Cilastatin across species; consult the dog dosing table above for species-specific guidance. Reserve for multi-drug resistant infections. May lower seizure threshold. Nausea and vomiting with rapid IV infusion. Administer IV slowly over 20-30 minutes.
Why a species-specific page? Imipenem-Cilastatin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.