Imipenem-Cilastatin for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Imipenem-Cilastatin is used in dog for Multi-drug resistant infections. Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Imipenem-Cilastatin in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Primaxin
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 5–10 mg/kg | q6-8h | 7-14 days | Multi-drug resistant infections | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Binds penicillin-binding proteins, inhibiting cell wall synthesis. Ultra-broad spectrum including many resistant organisms. Cilastatin prevents renal metabolism of imipenem.
Side effects & warnings
Reserve for multi-drug resistant infections. May lower seizure threshold. Nausea and vomiting with rapid IV infusion. Administer IV slowly over 20-30 minutes.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Antibiotic drugs with dog dosing
Imipenem-Cilastatin dosing in other species
Why a species-specific page? Imipenem-Cilastatin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.