Pocket Pet · Cavia porcellus · typical adult weight 0.70–1.20 kg
Ketoconazole is dosed at 10–40 mg/kg PO q24h x 14 days in guinea pigs, per Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.772 (2026-08-01, PENDING REVIEW). Ketoconazole is used in guinea pigs for Systemic mycoses; candidiasis. Routes documented in guinea pigs: PO. A typical adult guinea pig weighs 0.70–1.20 kg. ExoticRx lists 1 cited dose rule for Ketoconazole in guinea pigs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Nizoral
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| PO | 10–40 mg/kg | q24h x 14 days | Systemic mycoses; candidiasis | Moderate | Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.772 (2026-08-01, PENDING REVIEW) |
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These ranges are per kg. Enter your guinea pig's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits lanosterol 14-alpha-demethylase (CYP51), blocking ergosterol synthesis in fungal membranes. At high doses, inhibits adrenal and gonadal steroidogenesis.
Hepatotoxic — monitor liver enzymes. Strong CYP inhibitor (many drug interactions). Requires gastric acid for absorption (do not give with antacids). Also used for Cushing's disease (adrenal steroidogenesis inhibition).
Species-specific contraindications and adverse-reaction reports for guinea pigs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ketoconazole dose range in guinea pigs, with cited source references: PO 10–40 mg/kg q24h x 14 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ketoconazole in guinea pigs: PO.
Ketoconazole is indicated in guinea pigs for: Systemic mycoses; candidiasis.
These are general warnings for Ketoconazole across species; consult the guinea pig dosing table above for species-specific guidance. Hepatotoxic — monitor liver enzymes. Strong CYP inhibitor (many drug interactions). Requires gastric acid for absorption (do not give with antacids). Also used for Cushing's disease (adrenal steroidogenesis inhibition).
Why a species-specific page? Ketoconazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in guinea pigs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.