ExoticRx · exoticrx.com/drugs/lacosamide
US brand names:Vimpat
Lacosamide is dosed at 5–10 mg/kg IV IV bolus over 15 min, then transition to PO in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Enhances slow inactivation of voltage-gated sodium channels, selectively stabilizing hyperexcitable neuronal membranes. Also binds CRMP-2 mediating neurite outgrowth.
May cause PR interval prolongation — monitor ECG. Dose-dependent dizziness and ataxia. Schedule V controlled substance. Limited veterinary pharmacokinetic data.
Species references:All Dog (Domestic) drugs
Controlled substance in the US
Controlled-drug status and schedules differ by country — check your local scheduling rules.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.