Lincomycin (Livestock) for Swine

Livestock · Sus scrofa domesticus · typical adult weight 1.00–300.00 kg

Lincomycin (Livestock) is dosed at 5–10 mg/kg PO Continuous in water in swine, per LINCOCIN®- Lincomycin Hydrochloride Monohydrate Liquid (Solution) [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2019. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.789 (2026-08-01). — Plumb's 10th ed (held) printed p.760, Lincomycin monograph spanning p.760-761; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — 21 CFR § 520.1263b (Lincomycin powder), conditions of use for Swine: 8.3776-8.3776 mg/kg (the regulation prints this per pound; converted at 2.2046226 lb/kg). Related tolerances: 21 CFR § 556.360. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-520.1263b — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Lincomycin (Livestock) is used in swine for Mycoplasma pneumonia, swine dysentery. Routes documented in swine: PO. A typical adult swine weighs 1.00–300.00 kg. ExoticRx lists 1 cited dose rule for Lincomycin (Livestock) in swine, drawn from published veterinary references. Verify against current literature before clinical use.

US trade names: Lincomix

Contraindicated in Mouse, Pet Rat, Gerbil, Prairie Dog, Horse (Equine), Cattle / Sheep / Goat, Rabbit, Chinchilla, Hamster, Degu, Guinea Pig

Mouse: Lincosamides cause fatal diarrhea in MousePlumb's states of the lincosamides: "Do NOT give this medicine to horses, cattle, sheep, goats, deer, rabbits, mice, rats, hamsters, or guinea pigs, as it may cause fatal diarrhea," and elsewhere that "the lincosamides are considered contraindicated for use in horses, ruminants, rabbits." The mechanism is the same selective destruction of gram-positive gut flora that kills rabbits. Added 2026-08-11 after an audit found this species unreachable by any token, so this warning could never fire for it.
Pet Rat: Lincosamides cause fatal diarrhea in Pet RatPlumb's states of the lincosamides: "Do NOT give this medicine to horses, cattle, sheep, goats, deer, rabbits, mice, rats, hamsters, or guinea pigs, as it may cause fatal diarrhea," and elsewhere that "the lincosamides are considered contraindicated for use in horses, ruminants, rabbits." The mechanism is the same selective destruction of gram-positive gut flora that kills rabbits. Added 2026-08-11 after an audit found this species unreachable by any token, so this warning could never fire for it.
Gerbil: Lincosamides cause fatal diarrhea in GerbilPlumb's states of the lincosamides: "Do NOT give this medicine to horses, cattle, sheep, goats, deer, rabbits, mice, rats, hamsters, or guinea pigs, as it may cause fatal diarrhea," and elsewhere that "the lincosamides are considered contraindicated for use in horses, ruminants, rabbits." The mechanism is the same selective destruction of gram-positive gut flora that kills rabbits. Added 2026-08-11 after an audit found this species unreachable by any token, so this warning could never fire for it.
Prairie Dog: Lincosamides cause fatal diarrhea in Prairie DogPlumb's states of the lincosamides: "Do NOT give this medicine to horses, cattle, sheep, goats, deer, rabbits, mice, rats, hamsters, or guinea pigs, as it may cause fatal diarrhea," and elsewhere that "the lincosamides are considered contraindicated for use in horses, ruminants, rabbits." The mechanism is the same selective destruction of gram-positive gut flora that kills rabbits. Added 2026-08-11 after an audit found this species unreachable by any token, so this warning could never fire for it.
Horse (Equine): Lincosamides cause fatal diarrhea in Horse (Equine)Plumb's states of the lincosamides: "Do NOT give this medicine to horses, cattle, sheep, goats, deer, rabbits, mice, rats, hamsters, or guinea pigs, as it may cause fatal diarrhea," and elsewhere that "the lincosamides are considered contraindicated for use in horses, ruminants, rabbits." The mechanism is the same selective destruction of gram-positive gut flora that kills rabbits. Added 2026-08-11 after an audit found this species unreachable by any token, so this warning could never fire for it.
Cattle / Sheep / Goat: Lincosamides cause fatal diarrhea in Cattle / Sheep / GoatPlumb's states of the lincosamides: "Do NOT give this medicine to horses, cattle, sheep, goats, deer, rabbits, mice, rats, hamsters, or guinea pigs, as it may cause fatal diarrhea," and elsewhere that "the lincosamides are considered contraindicated for use in horses, ruminants, rabbits." The mechanism is the same selective destruction of gram-positive gut flora that kills rabbits. Added 2026-08-11 after an audit found this species unreachable by any token, so this warning could never fire for it.
Rabbit: Oral lincosamides cause fatal dysbiosis in rabbitsSame mechanism as oral beta-lactams — selective destruction of gram-positive hindgut flora. Never administer oral clindamycin or lincomycin to rabbits.
Chinchilla: Oral lincosamides cause fatal dysbiosis in chinchillasClindamycin and lincomycin destroy gram-positive hindgut flora and precipitate fatal Clostridium enterotoxemia in chinchillas. Never administer.
Hamster: Oral lincosamides cause fatal enterocolitis in hamstersClindamycin and lincomycin are among the antibiotics that induce fatal Clostridium difficile enterocolitis in hamsters. Never administer.
Degu: Oral lincosamides risk fatal dysbiosis in degusExtrapolated from chinchillas and guinea pigs (shared caviomorph hindgut physiology): oral clindamycin/lincomycin should be treated as contraindicated in degus.
Guinea Pig: Oral lincosamides cause fatal dysbiosis in guinea pigsClindamycin and lincomycin cause the same fatal Clostridium enterotoxemia in guinea pigs as oral beta-lactams. Never administer.

Dose ranges

Route	Dose	Frequency	Duration	Indication	Evidence	Source
PO	5–10 mg/kg	Continuous in water	7-14 days	Mycoplasma pneumonia, swine dysentery	Strong	LINCOCIN®- Lincomycin Hydrochloride Monohydrate Liquid (Solution) [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2019. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.789 (2026-08-01). — Plumb's 10th ed (held) printed p.760, Lincomycin monograph spanning p.760-761; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — 21 CFR § 520.1263b (Lincomycin powder), conditions of use for Swine: 8.3776-8.3776 mg/kg (the regulation prints this per pound; converted at 2.2046226 lb/kg). Related tolerances: 21 CFR § 556.360. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-520.1263b — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207

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Mechanism of action

Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. Effective against gram-positive organisms and Mycoplasma spp.

Side effects & warnings

Swine use primarily. Do NOT administer to ruminants, horses, or rabbits — causes fatal enterocolitis. Observe meat withdrawal periods.

Species-specific contraindications and adverse-reaction reports for swine may differ from canine / feline reference data — consult the primary citations listed with each rule.

Frequently asked questions

What is the dose of Lincomycin (Livestock) for Swine?

Lincomycin (Livestock) dose range in swine, with cited source references: PO 5–10 mg/kg Continuous in water. Reference ranges from cited sources — verify against current literature before clinical use.

How is Lincomycin (Livestock) administered in Swine?

Documented routes for Lincomycin (Livestock) in swine: PO.

How long is Lincomycin (Livestock) given in Swine?

Cited course lengths for Lincomycin (Livestock) in swine include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.

What conditions does Lincomycin (Livestock) treat in Swine?

Lincomycin (Livestock) is indicated in swine for: Mycoplasma pneumonia, swine dysentery.

What are the side effects of Lincomycin (Livestock) in Swine?

These are general warnings for Lincomycin (Livestock) across species; consult the swine dosing table above for species-specific guidance. Swine use primarily. Do NOT administer to ruminants, horses, or rabbits — causes fatal enterocolitis. Observe meat withdrawal periods.

Other Antibiotic drugs with swine dosing

Amoxicillin Ampicillin Bacitracin (Livestock Feed)Bambermycin Carbadox Cefquinome (Livestock)Ceftiofur Ceftiofur Crystalline Free Acid (Long-Acting)Florfenicol Oxytetracycline Spectinomycin (Livestock)Sulfamethazine

Lincomycin (Livestock) dosing in other species

Chickens

See all species for Lincomycin (Livestock)See all drugs for Swine

Why a species-specific page? Lincomycin (Livestock) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in swine — the rules above are the citations specific to this species, not generic recommendations.

Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.