Livestock · Sus scrofa domesticus · typical adult weight 1.00–300.00 kg
Ampicillin is dosed at 6.6–11 mg/kg IM q12-24h in swine, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.78, Ampicillin monograph spanning p.78-81; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.80, Ampicillin monograph; the page cited previously does not carry it. — 21 CFR § 522.90a (Ampicillin trihydrate suspension), conditions of use for Swine: 6.6139-6.6139 mg/kg (the regulation prints this per pound; converted at 2.2046226 lb/kg). Related tolerances: 21 CFR § 556.40. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-522.90a — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Ampicillin is used in swine for Bacterial enteritis (colibacillosis, E. coli) and bacterial pneumonia (Pasteurella spp). Routes documented in swine: IM. A typical adult swine weighs 1.00–300.00 kg. ExoticRx lists 1 cited dose rule for Ampicillin in swine, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Polyflex
Contraindicated in Rabbit, Guinea Pig, Chinchilla, Hamster, Degu
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 6.6–11 mg/kg | q12-24h | 3-5 days | Bacterial enteritis (colibacillosis, E. coli) and bacterial pneumonia (Pasteurella spp) | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.78, Ampicillin monograph spanning p.78-81; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.80, Ampicillin monograph; the page cited previously does not carry it. — 21 CFR § 522.90a (Ampicillin trihydrate suspension), conditions of use for Swine: 6.6139-6.6139 mg/kg (the regulation prints this per pound; converted at 2.2046226 lb/kg). Related tolerances: 21 CFR § 556.40. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-522.90a — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
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These ranges are per kg. Enter your swine's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Broader spectrum than penicillin G with gram-negative coverage.
CONTRAINDICATED in rabbits, guinea pigs, and hamsters (fatal dysbiosis). May cause GI upset. Cross-reactivity with other beta-lactams. IM injection may be painful.
Species-specific contraindications and adverse-reaction reports for swine may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ampicillin dose range in swine, with cited source references: IM 6.6–11 mg/kg q12-24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ampicillin in swine: IM.
Cited course lengths for Ampicillin in swine include: 3-5 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Ampicillin is indicated in swine for: Bacterial enteritis (colibacillosis, E. coli) and bacterial pneumonia (Pasteurella spp).
These are general warnings for Ampicillin across species; consult the swine dosing table above for species-specific guidance. CONTRAINDICATED in rabbits, guinea pigs, and hamsters (fatal dysbiosis). May cause GI upset. Cross-reactivity with other beta-lactams. IM injection may be painful.
Why a species-specific page? Ampicillin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in swine — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.