Cat · Felis catus · typical adult weight 2.50–7.00 kg
Methimazole Transdermal is dosed at 2.5–5 mg per cat Transdermal q12h in cats, per Sartor LL, Trepanier LA, Kroll MM, Rodan I, Challoner L. Efficacy and safety of transdermal methimazole in the treatment of cats with hyperthyroidism. J Vet Intern Med. 2004;18(5):651-655. | Lecuyer M, Prini S, Dunn ME, Douce MY. Clinical efficacy and safety of transdermal methimazole in the treatment of feline hyperthyroidism. Can Vet J. 2006;47:131-135. | Boretti FS, Sieber-Ruckstuhl NS, Schafer S, et al. Duration of T4 suppression in hyperthyroid cats treated once and twice daily with transdermal methimazole. J Vet Intern Med. 2013;27(2):377-381. doi:10.1111/j.1939-1676.2004.tb02601.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.878 (2026-08-01).. Methimazole Transdermal is used in cats for Hyperthyroidism. Routes documented in cats: Transdermal. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Methimazole Transdermal in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Methimazole PLO gel
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| Transdermal | 2.5–5 mg per cat | q12h | Long-term | Hyperthyroidism | Strong | Sartor LL, Trepanier LA, Kroll MM, Rodan I, Challoner L. Efficacy and safety of transdermal methimazole in the treatment of cats with hyperthyroidism. J Vet Intern Med. 2004;18(5):651-655. | Lecuyer M, Prini S, Dunn ME, Douce MY. Clinical efficacy and safety of transdermal methimazole in the treatment of feline hyperthyroidism. Can Vet J. 2006;47:131-135. | Boretti FS, Sieber-Ruckstuhl NS, Schafer S, et al. Duration of T4 suppression in hyperthyroid cats treated once and twice daily with transdermal methimazole. J Vet Intern Med. 2013;27(2):377-381. doi:10.1111/j.1939-1676.2004.tb02601.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.878 (2026-08-01). |
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Same as oral methimazole. Transdermal delivery through pinna skin avoids GI side effects. Inhibits thyroid peroxidase.
Applied to inner pinna of cat ears. Alternating ears. Handler wears gloves. Less GI upset than oral. Erratic absorption reported. Monitor T4.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Methimazole Transdermal dose range in cats, with cited source references: Transdermal 2.5–5 mg per cat q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Methimazole Transdermal in cats: Transdermal.
Cited course lengths for Methimazole Transdermal in cats include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Methimazole Transdermal is indicated in cats for: Hyperthyroidism.
These are general warnings for Methimazole Transdermal across species; consult the cat dosing table above for species-specific guidance. Applied to inner pinna of cat ears. Alternating ears. Handler wears gloves. Less GI upset than oral. Erratic absorption reported. Monitor T4.
Why a species-specific page? Methimazole Transdermal pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.