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Midazolam for Guinea Pig

Pocket Pet · Cavia porcellus · typical adult weight 0.70–1.20 kg

Midazolam is used in guinea pig for Pre-anesthetic sedation, Seizure control. Routes documented in guinea pig: IM, IV. A typical adult guinea pig weighs 0.70–1.20 kg. ExoticRx lists 2 cited dose rules for Midazolam in guinea pig, drawn from published veterinary references. Verify against current literature before clinical use.

Trade names: Versed

Dose ranges

RouteDoseFrequencyDurationIndicationEvidenceSource
IM0.5–2 mg/kgonceSingle dosePre-anesthetic sedationModerateCarpenter's Exotic Animal Formulary, 6th Ed
IV0.5–2 mg/kgq5minUntil controlledSeizure controlModerateCarpenter's Exotic Animal Formulary, 6th Ed

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These ranges are per kg. Enter your guinea pig's weight to get the precise dose and draw-up volume — unit and concentration math done for you.

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Mechanism of action

Enhances GABA-A receptor activity, increasing chloride conductance. Provides anxiolysis, sedation, muscle relaxation, and anticonvulsant effects.

Side effects & warnings

May cause paradoxical excitement in healthy dogs when used alone. Water-soluble (less painful IM than diazepam). Respiratory depression at high doses. Flumazenil is the reversal agent.

Species-specific contraindications and adverse-reaction reports for guinea pig may differ from canine / feline reference data — consult the primary citations listed with each rule.

Other Anesthetic drugs with guinea pig dosing

Midazolam dosing in other species

Why a species-specific page? Midazolam pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in guinea pig — the rules above are the citations specific to this species, not generic recommendations.

Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.