ExoticRx · exoticrx.com/drugs/oclacitinib
US brand names:Apoquel
Oclacitinib is dosed at 0.4–0.6 mg/kg PO q12h x 14 days, then q24h in dogs, per APOQUEL - Oclacitinib Maleate Tablet, Coated [US Product Label for Dogs]. Kalamazoo, MI: Zoetis Inc.; 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a39a0298-6453-4c21-a3b0-01c1a52a109b — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.976 (2026-08-01).. Verify against current literature before clinical use.
Selectively inhibits JAK1 (and to lesser extent JAK3), blocking signaling of itch and inflammation cytokines (IL-31, IL-4, IL-13) involved in allergic dermatitis.
Dogs only (not cats). Rapid onset of anti-pruritic effect (within 4h). Not for use under 12 months age. Immunosuppression risk — not recommended with concurrent immunosuppressives. May increase susceptibility to demodicosis and infections.
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.4–0.6 mg/kg | q12h x 14 days, then q24h | Strong | APOQUEL - Oclacitinib Maleate Tablet, Coated [US Product Label for Dogs]. Kalamazoo, MI: Zoetis Inc.; 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a39a0298-6453-4c21-a3b0-01c1a52a109b — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.976 (2026-08-01). |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.