ExoticRx · exoticrx.com/drugs/oclacitinib
Oclacitinib
Apoquel
Drug Class
Routes
Indications
Mechanism of Action
Selectively inhibits JAK1 (and to lesser extent JAK3), blocking signaling of itch and inflammation cytokines (IL-31, IL-4, IL-13) involved in allergic dermatitis.
Side effects & warnings
Dogs only (not cats). Rapid onset of anti-pruritic effect (within 4h). Not for use under 12 months age. Immunosuppression risk — not recommended with concurrent immunosuppressives. May increase susceptibility to demodicosis and infections.
Species with Oclacitinib dosing data (1 dose rule)
Species references:All Dog (Domestic) drugs
Evidence levels across 1 dose rule
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by a published source
- · Plumb's Veterinary Drug Handbook, 9th Ed
Sample dosing (1 of 1 cited rule)
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.4–0.6 mg/kg | q12h x 14 days, then q24h | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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Source citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.