ExoticRx · exoticrx.com/drugs/olanzapine
US brand names:Zyprexa
Olanzapine is dosed at 0.1–0.25 mg/kg PO q24h in cats, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Antagonist at serotonin 5-HT2A/2C, dopamine D1-D4, muscarinic M1-M5, histamine H1, and alpha-1 adrenergic receptors. Broad receptor binding profile.
Weight gain and metabolic syndrome common. Sedation, especially at initiation. Risk of hepatotoxicity. Very limited veterinary data.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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