ExoticRx · exoticrx.com/drugs/pimecrolimus-topical
US brand names:Elidel
Binds macrophilin-12, inhibiting calcineurin and preventing T-cell activation and cytokine release. Selective for skin-resident immune cells.
Local burning sensation initially. Avoid on infected skin. Less potent than tacrolimus. Alternative for atopic dermatitis when tacrolimus is not tolerated.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | Topical | Non-steroidal calcineurin inhibitor | Apply thin layer q12h to affected area | Weak | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1492 (2026-08-01). |
| Cat (Domestic) | Topical | Alternative when tacrolimus is not tolerated | Apply thin layer q12h | Anecdotal | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1492 (2026-08-01). |
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