ExoticRx · exoticrx.com/drugs/poloxamer-407
US brand names:Pluronic F-127
Thermoreversible poloxamer gel that is liquid at cold temperatures and gels at body temperature. Used as vehicle for transdermal drug delivery of various active ingredients.
Compounding vehicle, not active drug. Systemic bioavailability of drugs in PLO gel is variable and often unpublished. Not all drugs are suitable for transdermal delivery. Ear pinna application common in cats.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | TRANSDERMAL | Dosing: per compounded formulation | Per active drug schedule | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| Dog (Domestic) | TRANSDERMAL | Dosing: per compounded formulation | Per active drug schedule | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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