ExoticRx · exoticrx.com/drugs/propylthiouracil
US brand names:PTU
Propylthiouracil is dosed at 50 mg per cat PO q12h in cats, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Inhibits thyroid peroxidase-mediated iodination and coupling reactions, and at high doses inhibits peripheral T4 to T3 conversion.
Higher hepatotoxicity and immune-mediated reactions than methimazole. Not recommended in cats — methimazole preferred. Monitor CBC and liver function.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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