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Sirolimus

Rapamune

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Immunosuppressant

Routes

PO

Indications

ImmunosuppressionImmunosuppression (investigational)investigational oncology

Mechanism of Action

Inhibits mammalian target of rapamycin (mTOR), blocking T-cell proliferation driven by IL-2. Also has antiproliferative effects on smooth muscle and tumor cells.

Side effects & warnings

Immunosuppression increases infection risk. Monitor CBC, liver, renal, and lipids. Drug interactions with CYP3A4 inhibitors. Limited veterinary data outside oncology research.

Species with Sirolimus dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs

Evidence levels across 2 dose rules

Weak×1Extrapolated×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · Papich Handbook of Veterinary Drugs, 5th Ed

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO0.05–0.1 mg/kgq24hWeakPapich Handbook of Veterinary Drugs, 5th Ed
Cat (Domestic)PO0.05–0.1 mg/kgq24hExtrapolatedPapich Handbook of Veterinary Drugs, 5th Ed

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Calculate Dosage for Sirolimus