ExoticRx · exoticrx.com/drugs/mycophenolate-mofetil
US brand names:CellCept
Mycophenolate Mofetil is dosed at 10–20 mg/kg PO q12h in dogs, per Abelson AL, Shelton GD, Whelan MF, Cornejo L, Shaw S, O'Toole TE. Use of mycophenolate mofetil as a rescue agent in the treatment of severe generalized myasthenia gravis in three dogs. J Vet Emerg Crit Care. 2009;19(4):369-374. doi:10.1111/j.1476-4431.2009.00433.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.949 (2026-08-01). — Plumb's 10th ed (held) printed p.921, Mycophenolate monograph spanning p.920-922; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Verify against current literature before clinical use.
Inhibits inosine monophosphate dehydrogenase, selectively blocking de novo purine synthesis in lymphocytes (which lack the salvage pathway).
GI side effects common (diarrhea, vomiting). More selective immunosuppression than azathioprine. Monitor CBC. Teratogenic. Used for immune-mediated hemolytic anemia, myasthenia gravis, and transplant rejection.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 10–20 mg/kg | q12h | Moderate | Abelson AL, Shelton GD, Whelan MF, Cornejo L, Shaw S, O'Toole TE. Use of mycophenolate mofetil as a rescue agent in the treatment of severe generalized myasthenia gravis in three dogs. J Vet Emerg Crit Care. 2009;19(4):369-374. doi:10.1111/j.1476-4431.2009.00433.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.949 (2026-08-01). — Plumb's 10th ed (held) printed p.921, Mycophenolate monograph spanning p.920-922; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Cat (Domestic) | PO | 10 mg/kg | q12h |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
| Bacek LM, Macintire DK. Treatment of primary immune-mediated hemolytic anemia with mycophenolate mofetil in two cats. J Vet Emerg Crit Care (San Antonio). 2011;21(1):45-49. doi:10.1111/j.1476-4431.2011.00642.x — Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.579 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.579' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.551; verified by finding the drug named there. If you are holding the book, turn to p.551. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 | CAUTION PRINTED ALONGSIDE THE DOSE, Plumb's Veterinary Drug Handbook, Mycophenolate monograph, printed p.949, CATS: "Adjunctive treatment of IMHA (extra-label): From a case report of 2 cats: mycophenolate 10 mg/kg PO […]" |