ExoticRx · exoticrx.com/drugs/mycophenolate-mofetil
US brand names:CellCept
Mycophenolate Mofetil is dosed at 10–20 mg/kg PO q12h in dogs, per Abelson AL, Shelton GD, Whelan MF, Cornejo L, Shaw S, O'Toole TE. Use of mycophenolate mofetil as a rescue agent in the treatment of severe generalized myasthenia gravis in three dogs. J Vet Emerg Crit Care. 2009;19(4):369-374. — Plumb's 10th ed printed p.921, Mycophenolate monograph spanning p.920-922. Verify against current literature before clinical use.
Inhibits inosine monophosphate dehydrogenase, selectively blocking de novo purine synthesis in lymphocytes (which lack the salvage pathway).
GI side effects common (diarrhea, vomiting). More selective immunosuppression than azathioprine. Monitor CBC. Teratogenic. Used for immune-mediated hemolytic anemia, myasthenia gravis, and transplant rejection.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 10–20 mg/kg | q12h | Moderate | Abelson AL, Shelton GD, Whelan MF, Cornejo L, Shaw S, O'Toole TE. Use of mycophenolate mofetil as a rescue agent in the treatment of severe generalized myasthenia gravis in three dogs. J Vet Emerg Crit Care. 2009;19(4):369-374. doi:10.1111/j.1476-4431.2009.00433.x — Plumb's 10th ed printed p.921, Mycophenolate monograph spanning p.920-922. |
| Cat (Domestic) | PO | 10 mg/kg | q12h | Weak | Bacek LM, Macintire DK. Treatment of primary immune-mediated hemolytic anemia with mycophenolate mofetil in two cats. J Vet Emerg Crit Care (San Antonio). 2011;21(1):45-49. doi:10.1111/j.1476-4431.2011.00642.x | CAUTION PRINTED ALONGSIDE THE DOSE, Plumb's Veterinary Drug Handbook, Mycophenolate monograph, printed p.949, CATS: "Adjunctive treatment of IMHA (extra-label): From a case report of 2 cats: mycophenolate 10 mg/kg PO […]" |
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