Cat · Felis catus · typical adult weight 2.50–7.00 kg
Spironolactone is dosed at 1–2 mg/kg PO q12h in cats, per Plumb's Veterinary Drug Handbook (held edition 10th, 2023), Spironolactone monograph, printed p.1177 (corpus p.1204), CATS section: "Adjunctive treatment of hypertension (extra-label): 1 - 2 mg/kg PO every 12 hours." Superscript 21 resolves to Acierno MJ, Brown S, Coleman AE, et al. ACVIM consensus statement: guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med. 2018;32(6):1803-1822.. Spironolactone is used in cats for Cardiomyopathy adjunct. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Spironolactone in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Aldactone
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–2 mg/kg | q12h | Long-term | Cardiomyopathy adjunct | Weak | Plumb's Veterinary Drug Handbook (held edition 10th, 2023), Spironolactone monograph, printed p.1177 (corpus p.1204), CATS section: "Adjunctive treatment of hypertension (extra-label): 1 - 2 mg/kg PO every 12 hours." Superscript 21 resolves to Acierno MJ, Brown S, Coleman AE, et al. ACVIM consensus statement: guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med. 2018;32(6):1803-1822. |
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Competitively blocks aldosterone at mineralocorticoid receptors in the distal nephron. Potassium-sparing diuretic with anti-fibrotic cardiac effects.
Hyperkalemia risk, especially with ACE inhibitors. Monitor electrolytes. Anti-androgenic effects (gynecomastia). Used in CHF as adjunct to furosemide. Give with food.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Spironolactone dose range in cats, with cited source references: PO 1–2 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Spironolactone in cats: PO.
Cited course lengths for Spironolactone in cats include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Spironolactone is indicated in cats for: Cardiomyopathy adjunct.
These are general warnings for Spironolactone across species; consult the cat dosing table above for species-specific guidance. Hyperkalemia risk, especially with ACE inhibitors. Monitor electrolytes. Anti-androgenic effects (gynecomastia). Used in CHF as adjunct to furosemide. Give with food.
Why a species-specific page? Spironolactone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.