Cat · Felis catus · typical adult weight 2.50–7.00 kg
Spironolactone is dosed at 1–2 mg/kg PO q12h in cats, per Plumb's Veterinary Drug Handbook (held edition 10th, 2023), Spironolactone monograph, printed p.1177 (corpus p.1204), CATS section: "Adjunctive treatment of hypertension (extra-label): 1 - 2 mg/kg PO every 12 hours." Superscript 21 resolves to Acierno MJ, Brown S, Coleman AE, et al. ACVIM consensus statement: guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med. 2018;32(6):1803-1822. — Plumb's 10th ed (held) printed p.1175, Spironolactone monograph spanning p.1175-1176; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Spironolactone is used in cats for Systemic hypertension (adjunctive, extra-label, not first-line). Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Spironolactone in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Aldactone
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–2 mg/kg | q12h | Long-term | Systemic hypertension (adjunctive, extra-label, not first-line) | Weak | Plumb's Veterinary Drug Handbook (held edition 10th, 2023), Spironolactone monograph, printed p.1177 (corpus p.1204), CATS section: "Adjunctive treatment of hypertension (extra-label): 1 - 2 mg/kg PO every 12 hours." Superscript 21 resolves to Acierno MJ, Brown S, Coleman AE, et al. ACVIM consensus statement: guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med. 2018;32(6):1803-1822. — Plumb's 10th ed (held) printed p.1175, Spironolactone monograph spanning p.1175-1176; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2–4 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.402 | 2-4 mg/kg p.o. q24h. |
| 2–4 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.768 | efficacy is questionable. However, doses in the range of 2-4 mg/kg/day (or |
| 1–2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.768 | 1-2 mg/kg q12h) PO have been administered for some conditions. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Competitively blocks aldosterone at mineralocorticoid receptors in the distal nephron. Potassium-sparing diuretic with anti-fibrotic cardiac effects.
Hyperkalemia risk, especially with ACE inhibitors. Monitor electrolytes. Anti-androgenic effects (gynecomastia). Used in CHF as adjunct to furosemide. Give with food.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Spironolactone dose range in cats, with cited source references: PO 1–2 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Spironolactone in cats: PO.
Cited course lengths for Spironolactone in cats include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Spironolactone is indicated in cats for: Systemic hypertension (adjunctive, extra-label, not first-line).
These are general warnings for Spironolactone across species; consult the cat dosing table above for species-specific guidance. Hyperkalemia risk, especially with ACE inhibitors. Monitor electrolytes. Anti-androgenic effects (gynecomastia). Used in CHF as adjunct to furosemide. Give with food.
Why a species-specific page? Spironolactone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.