Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Spironolactone is dosed at 1–2 mg/kg PO q12h in dogs, per Acierno MJ, Brown S, Coleman AE, et al. ACVIM consensus statement: guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med. 2018;32(6):1803-1822. doi:10.1111/jvim.15331 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1204 (2026-08-01).. Spironolactone is used in dogs for CHF adjunct (with furosemide). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Spironolactone in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Aldactone
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–2 mg/kg | q12h | Long-term | CHF adjunct (with furosemide) | Moderate | Acierno MJ, Brown S, Coleman AE, et al. ACVIM consensus statement: guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med. 2018;32(6):1803-1822. doi:10.1111/jvim.15331 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1204 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Competitively blocks aldosterone at mineralocorticoid receptors in the distal nephron. Potassium-sparing diuretic with anti-fibrotic cardiac effects.
Hyperkalemia risk, especially with ACE inhibitors. Monitor electrolytes. Anti-androgenic effects (gynecomastia). Used in CHF as adjunct to furosemide. Give with food.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Spironolactone dose range in dogs, with cited source references: PO 1–2 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Spironolactone in dogs: PO.
Cited course lengths for Spironolactone in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Spironolactone is indicated in dogs for: CHF adjunct (with furosemide).
These are general warnings for Spironolactone across species; consult the dog dosing table above for species-specific guidance. Hyperkalemia risk, especially with ACE inhibitors. Monitor electrolytes. Anti-androgenic effects (gynecomastia). Used in CHF as adjunct to furosemide. Give with food.
Why a species-specific page? Spironolactone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.