Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Digoxin is dosed at 0.005–0.01 mg/kg PO q12h in dogs, per Pariaut R. Atrial Fibrillation Current Therapies. Veterinary Clinics of North America-Small Animal Practice. 2017;47(5):977-+. PMID: 41079340 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.421 (2026-08-01).. Digoxin is used in dogs for Supraventricular tachycardia, dilated cardiomyopathy. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Digoxin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Lanoxin, Cardoxin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.005–0.01 mg/kg | q12h | Long-term (serum level guided) | Supraventricular tachycardia, dilated cardiomyopathy | Strong | Pariaut R. Atrial Fibrillation Current Therapies. Veterinary Clinics of North America-Small Animal Practice. 2017;47(5):977-+. PMID: 41079340 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.421 (2026-08-01). |
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Inhibits Na+/K+-ATPase, increasing intracellular calcium, enhancing contractility (positive inotrope). Also slows AV conduction (vagomimetic).
NARROW therapeutic index. Monitor serum digoxin levels (target 1.0-2.0 ng/ml dogs). Toxicity: arrhythmias, anorexia, vomiting. Reduce dose in renal failure. Many drug interactions (quinidine, verapamil).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Digoxin dose range in dogs, with cited source references: PO 0.005–0.01 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Digoxin in dogs: PO.
Cited course lengths for Digoxin in dogs include: Long-term (serum level guided). Duration depends on the indication — match it to the specific dose rule in the table above.
Digoxin is indicated in dogs for: Supraventricular tachycardia, dilated cardiomyopathy.
These are general warnings for Digoxin across species; consult the dog dosing table above for species-specific guidance. NARROW therapeutic index. Monitor serum digoxin levels (target 1.0-2.0 ng/ml dogs). Toxicity: arrhythmias, anorexia, vomiting. Reduce dose in renal failure. Many drug interactions (quinidine, verapamil).
Why a species-specific page? Digoxin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.