Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Digoxin is dosed at 0.005–0.01 mg/kg PO q12h in dogs, per Pariaut R. Atrial Fibrillation Current Therapies. Veterinary Clinics of North America-Small Animal Practice. 2017;47(5):977-+. PMID: 41079340 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.421 (2026-08-01). — Plumb's 10th ed (held) printed p.392, Digoxin monograph spanning p.392-395; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Digoxin is used in dogs for Supraventricular tachycardia, dilated cardiomyopathy. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Digoxin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Lanoxin, Cardoxin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.005–0.01 mg/kg | q12h | Long-term (serum level guided) | Supraventricular tachycardia, dilated cardiomyopathy | Strong | Pariaut R. Atrial Fibrillation Current Therapies. Veterinary Clinics of North America-Small Animal Practice. 2017;47(5):977-+. PMID: 41079340 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.421 (2026-08-01). — Plumb's 10th ed (held) printed p.392, Digoxin monograph spanning p.392-395; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mcg/kg) | Route | Source | As printed |
|---|---|---|---|
| 3.5 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.140 | 2.5-3.5 μg (micrograms)/kg p.o. q12h based on lean body weight (decrease dose by 10% for elixir). Maximum dose 0.25 |
| 2.2–4.4 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.140 | eutic levels. Only use i.v. if essentially indicated: 2.2-4.4 μg/kg i.v. q12h |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Inhibits Na+/K+-ATPase, increasing intracellular calcium, enhancing contractility (positive inotrope). Also slows AV conduction (vagomimetic).
NARROW therapeutic index. Monitor serum digoxin levels (target 1.0-2.0 ng/ml dogs). Toxicity: arrhythmias, anorexia, vomiting. Reduce dose in renal failure. Many drug interactions (quinidine, verapamil).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Digoxin dose range in dogs, with cited source references: PO 0.005–0.01 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Digoxin in dogs: PO.
Cited course lengths for Digoxin in dogs include: Long-term (serum level guided). Duration depends on the indication — match it to the specific dose rule in the table above.
Digoxin is indicated in dogs for: Supraventricular tachycardia, dilated cardiomyopathy.
These are general warnings for Digoxin across species; consult the dog dosing table above for species-specific guidance. NARROW therapeutic index. Monitor serum digoxin levels (target 1.0-2.0 ng/ml dogs). Toxicity: arrhythmias, anorexia, vomiting. Reduce dose in renal failure. Many drug interactions (quinidine, verapamil).
Why a species-specific page? Digoxin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.