ExoticRx · exoticrx.com/drugs/digoxin
US brand names:Lanoxin, Cardoxin
Digoxin is dosed at 0.005–0.01 mg/kg PO q12h in dogs, per Pariaut R. Atrial Fibrillation Current Therapies. Veterinary Clinics of North America-Small Animal Practice. 2017;47(5):977-+. PMID: 41079340 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.421 (2026-08-01).. Verify against current literature before clinical use.
Inhibits Na+/K+-ATPase, increasing intracellular calcium, enhancing contractility (positive inotrope). Also slows AV conduction (vagomimetic).
NARROW therapeutic index. Monitor serum digoxin levels (target 1.0-2.0 ng/ml dogs). Toxicity: arrhythmias, anorexia, vomiting. Reduce dose in renal failure. Many drug interactions (quinidine, verapamil).
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.005–0.01 mg/kg | q12h | Strong | Pariaut R. Atrial Fibrillation Current Therapies. Veterinary Clinics of North America-Small Animal Practice. 2017;47(5):977-+. PMID: 41079340 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.421 (2026-08-01). |
| Cat (Domestic) | PO | 0.005–0.01 mg/kg | q48h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.