ExoticRx · exoticrx.com/drugs/amiodarone
US brand names:Cordarone, Pacerone
Amiodarone is dosed at 10–15 mg/kg PO q12h loading x 7d, then q24h in dogs, per Saunders AB, Miller MW, Gordon SG, Van De Wiele CM. Oral amiodarone therapy in dogs with atrial fibrillation. J Vet Intern Med. 2006;20(4):921-926. doi:10.1111/j.1939-1676.2006.tb01806.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.85 (2026-08-01).. Verify against current literature before clinical use.
Class III antiarrhythmic blocking potassium, sodium, and calcium channels plus beta-adrenergic receptors. Prolongs action potential duration and refractory period.
Very long half-life (weeks). Hepatotoxicity, pulmonary fibrosis, thyroid dysfunction (contains iodine). Monitor liver, thyroid, and lung function. Numerous drug interactions.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 10–15 mg/kg | q12h loading x 7d, then q24h | Moderate | Saunders AB, Miller MW, Gordon SG, Van De Wiele CM. Oral amiodarone therapy in dogs with atrial fibrillation. J Vet Intern Med. 2006;20(4):921-926. doi:10.1111/j.1939-1676.2006.tb01806.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.85 (2026-08-01). |
| Dog (Domestic) | IV | 5–10 mg/kg | IV loading over 30-60 min | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.