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Amiodarone

Cordarone, Pacerone

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Cardiovascular

Routes

POIV

Indications

Life-threatening ventricular arrhythmiasRefractory ventricular arrhythmias

Mechanism of Action

Class III antiarrhythmic blocking potassium, sodium, and calcium channels plus beta-adrenergic receptors. Prolongs action potential duration and refractory period.

Side effects & warnings

Very long half-life (weeks). Hepatotoxicity, pulmonary fibrosis, thyroid dysfunction (contains iodine). Monitor liver, thyroid, and lung function. Numerous drug interactions.

Species with Amiodarone dosing data (2 dose rules)

Dog (Domestic)

Species references:All Dog (Domestic) drugs

Evidence levels across 2 dose rules

Moderate×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO10–15 mg/kgq12h loading x 7d, then q24hModeratePlumb's Veterinary Drug Handbook, 9th Ed
Dog (Domestic)IV5–10 mg/kgIV loading over 30-60 minModeratePlumb's Veterinary Drug Handbook, 9th Ed

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Calculate Dosage for Amiodarone