ExoticRx · exoticrx.com/drugs/bosentan
US brand names:Tracleer
Bosentan is dosed at 1–3 mg/kg PO q12h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Dual endothelin receptor (ET-A and ET-B) antagonist. Reduces pulmonary vascular resistance and mean pulmonary arterial pressure.
Used for pulmonary hypertension in dogs. Hepatotoxic — monthly liver enzyme monitoring required. Teratogenic. Drug interactions via CYP enzymes.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–3 mg/kg | q12h | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.