Pocket Pet · Oryctolagus cuniculus · typical adult weight 1.00–5.00 kg
Spironolactone is dosed at 1–2 mg/kg PO q12h in rabbits, per van Zeeland YR.A, Schoemaker NJ. Diagnosis and treatment of cardiovascular disease in small mammals. Proc Conf Annu Assoc Exot Mam Vet; 2018:607-616. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.872 (2026-08-01, PENDING REVIEW). Spironolactone is used in rabbits for Diuretic (potassium-sparing). Routes documented in rabbits: PO. A typical adult rabbit weighs 1.00–5.00 kg. ExoticRx lists 1 cited dose rule for Spironolactone in rabbits, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Aldactone
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| PO | 1–2 mg/kg | q12h | Diuretic (potassium-sparing) | Moderate | van Zeeland YR.A, Schoemaker NJ. Diagnosis and treatment of cardiovascular disease in small mammals. Proc Conf Annu Assoc Exot Mam Vet; 2018:607-616. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.872 (2026-08-01, PENDING REVIEW) |
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These ranges are per kg. Enter your rabbit's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Competitively blocks aldosterone at mineralocorticoid receptors in the distal nephron. Potassium-sparing diuretic with anti-fibrotic cardiac effects.
Hyperkalemia risk, especially with ACE inhibitors. Monitor electrolytes. Anti-androgenic effects (gynecomastia). Used in CHF as adjunct to furosemide. Give with food.
Species-specific contraindications and adverse-reaction reports for rabbits may differ from canine / feline reference data — consult the primary citations listed with each rule.
Spironolactone dose range in rabbits, with cited source references: PO 1–2 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Spironolactone in rabbits: PO.
Spironolactone is indicated in rabbits for: Diuretic (potassium-sparing).
These are general warnings for Spironolactone across species; consult the rabbit dosing table above for species-specific guidance. Hyperkalemia risk, especially with ACE inhibitors. Monitor electrolytes. Anti-androgenic effects (gynecomastia). Used in CHF as adjunct to furosemide. Give with food.
Why a species-specific page? Spironolactone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in rabbits — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.