Pocket Pet · Mus musculus · typical adult weight 0.02–0.04 kg
Sustained-release buprenorphine is dosed at 0.6 mg/kg SC q72h in mice, per Kendall LV, Wegenast DJ, Smith BJ, et al. Efficacy of sustained-release buprenorphine in an experimental laparotomy model in female mice. J Am Assoc Lab Anim Sci. 2016;55:66-73. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.790 (2026-08-01). — Carpenter's Exotic Animal Formulary 6th ed, Table 9.4 (Analgesic Agents Used in Rodents). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Sustained-release buprenorphine is used in mice for Analgesia in a surgical model of pain (analgesia for at least 48 h). NOTE: reported by the paper as a finding of 'previous studies' (cited comparator), not a dose administered in this study., post-operative analgesia (incisional pain model). Routes documented in mice: SC. A typical adult mouse weighs 0.02–0.04 kg. ExoticRx lists 2 cited dose rules for Sustained-release buprenorphine in mice, drawn from published veterinary references. Verify against current literature before clinical use.
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| SC | 0.6 mg/kg | q72h | Analgesia in a surgical model of pain (analgesia for at least 48 h). NOTE: reported by the paper as a finding of 'previous studies' (cited comparator), not a dose administered in this study. |
| Weak |
| Kendall LV, Wegenast DJ, Smith BJ, et al. Efficacy of sustained-release buprenorphine in an experimental laparotomy model in female mice. J Am Assoc Lab Anim Sci. 2016;55:66-73. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.790 (2026-08-01). — Carpenter's Exotic Animal Formulary 6th ed, Table 9.4 (Analgesic Agents Used in Rodents). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929 |
| SC | 1 mg/kg | once | post-operative analgesia (incisional pain model) | Weak | Navarro KL, et al. Lipid bound extended release buprenorphine (high and low doses) and sustained release buprenorphine effectively attenuate post-operative hypersensitivity in an incisional pain model in mice (Mus musculus). Animal Models and Experimental Medicine. 2021. DOI 10.1002/ame2.12157; PMID 34179720; PMCID PMC8212827. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC8212827/ |
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Sustained-release buprenorphine dose ranges in mice, with cited source references: SC 0.6 mg/kg q72h; SC 1 mg/kg once. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Sustained-release buprenorphine in mice: SC.
Sustained-release buprenorphine is indicated in mice for: Analgesia in a surgical model of pain (analgesia for at least 48 h). NOTE: reported by the paper as a finding of 'previous studies' (cited comparator), not a dose administered in this study., post-operative analgesia (incisional pain model).
Why a species-specific page? Sustained-release buprenorphine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in mice — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.