ExoticRx · exoticrx.com/drugs/tacrolimus-oral
US brand names:Prograf
Tacrolimus Oral is dosed at 0.05–0.1 mg/kg PO q12h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Binds FKBP12, inhibiting calcineurin and blocking IL-2 transcription. More potent immunosuppressant than cyclosporine (10-100x in vitro).
Nephrotoxic and diabetogenic. Monitor drug levels, renal function, and blood glucose. Drug interactions with CYP3A4 substrates. Very narrow therapeutic index.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.05–0.1 mg/kg | q12h | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
| Cat (Domestic) | PO | 0.05–0.1 mg/kg | q12h | Extrapolated | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.