ExoticRx · exoticrx.com/drugs/tofacitinib
US brand names:Xeljanz
Tofacitinib is dosed at 0.5–1 mg/kg PO q12h in dogs, per Papich Handbook of Veterinary Drugs, 5th Ed. Verify against current literature before clinical use.
Janus kinase (JAK1/JAK3) inhibitor that blocks signaling of multiple cytokines involved in inflammation and immune response (IL-2, IL-4, IL-6, IL-15, IL-21, IFN).
Investigational in veterinary medicine. Immunosuppression, infection risk. Monitor CBC. May cause GI upset. Potentially useful for immune-mediated diseases unresponsive to standard therapy.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.5–1 mg/kg | q12h | Extrapolated | Papich Handbook of Veterinary Drugs, 5th Ed |
| Cat (Domestic) | PO | 0.5–1 mg/kg | q12h | Extrapolated | Papich Handbook of Veterinary Drugs, 5th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.