Trimethoprim-Sulfamethoxazole for Leopard Geckos
Reptile · Eublepharis macularius · typical adult weight 0.04–0.10 kg
Trimethoprim-Sulfamethoxazole is dosed at 30 mg/kg PO s.i.d. (once daily) in leopard geckos, per Coke RL, Tristan TE. Cryptosporidium Infection in a Colony of Leopard Geckos, Eublepharis macularius. 1998 Proceedings, Association of Reptilian and Amphibian Veterinarians: 157-165. URL: https://cdn.ymaws.com/members.arav.org/resource/resmgr/Files/Proceedings_1998/1998_38.pdf. Trimethoprim-Sulfamethoxazole is used in leopard geckos for E. coli enteritis (culture/sensitivity-selected). Routes documented in leopard geckos: PO. A typical adult leopard gecko weighs 0.04–0.10 kg. ExoticRx lists 1 cited dose rule for Trimethoprim-Sulfamethoxazole in leopard geckos, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Bactrim, TMS
Dose ranges
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| PO | 30 mg/kg | s.i.d. (once daily) | E. coli enteritis (culture/sensitivity-selected) | Anecdotal | Coke RL, Tristan TE. Cryptosporidium Infection in a Colony of Leopard Geckos, Eublepharis macularius. 1998 Proceedings, Association of Reptilian and Amphibian Veterinarians: 157-165. URL: https://cdn.ymaws.com/members.arav.org/resource/resmgr/Files/Proceedings_1998/1998_38.pdf |
Need the exact dose for your patient?
These ranges are per kg. Enter your leopard gecko's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Sequential blockade of folate synthesis: sulfamethoxazole inhibits dihydropteroate synthase; trimethoprim inhibits dihydrofolate reductase.
Side effects & warnings
May cause keratoconjunctivitis sicca (KCS) in dogs with prolonged use. Can cause bone marrow suppression. Avoid in animals with hepatic disease. Adequate hydration required.
Species-specific contraindications and adverse-reaction reports for leopard geckos may differ from canine / feline reference data — consult the primary citations listed with each rule.
Frequently asked questions
What is the dose of Trimethoprim-Sulfamethoxazole for Leopard Geckos?
Trimethoprim-Sulfamethoxazole dose range in leopard geckos, with cited source references: PO 30 mg/kg s.i.d. (once daily).
How is Trimethoprim-Sulfamethoxazole administered in Leopard Geckos?
Documented routes for Trimethoprim-Sulfamethoxazole in leopard geckos: PO.
What conditions does Trimethoprim-Sulfamethoxazole treat in Leopard Geckos?
Trimethoprim-Sulfamethoxazole is indicated in leopard geckos for: E. coli enteritis (culture/sensitivity-selected).
What are the side effects of Trimethoprim-Sulfamethoxazole in Leopard Geckos?
These are general warnings for Trimethoprim-Sulfamethoxazole across species; consult the leopard gecko dosing table above for species-specific guidance. May cause keratoconjunctivitis sicca (KCS) in dogs with prolonged use. Can cause bone marrow suppression. Avoid in animals with hepatic disease. Adequate hydration required.
Other Antibiotic drugs with leopard gecko dosing
Trimethoprim-Sulfamethoxazole dosing in other species
Why a species-specific page? Trimethoprim-Sulfamethoxazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in leopard geckos — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.