Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.
Trimethoprim-Sulfamethoxazole is dosed at 15–25 mg/kg/day IM q24h for 7 to 14 days in bearded dragons, per Plumb's Veterinary Drug Handbook, 9th ed., Sulfa-/Trimethoprim monograph, REPTILES section entry c), printed p.1196 (corpus PDF p.1223), superscript 46 → Lewbart. Reptile formulary. Presented at: Atlantic Coast Veterinary Conference; 2001. Verify against current literature before clinical use.
May cause keratoconjunctivitis sicca (KCS) in dogs with prolonged use. Can cause bone marrow suppression. Avoid in animals with hepatic disease. Adequate hydration required.
Species with Trimethoprim-Sulfamethoxazole dosing data (25 dose rules)
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by 17 published sources
· Bodley K. Appendix 4. Drug Formulary. In: Vogelnest L, Portas T, eds. Current Therapy in Medicine of Australian Mammals; CSIRO Publishing, Clayton South, Vic; 2019:702-727.; Morrisey JK, Carpenter JW, et al. Formulary. In: Quesenberry KE, Orcutt CJ, Mans C, et al. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.705 (2026-08-01).
· Carpenter's Exotic Animal Formulary, 6th Ed
· EQUISUL-SDT - Sulfadiazine and Trimethoprim Suspension [US Product Label for Horses]. Aurora Pharmaceutical, Inc.; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=434cfb08-bb19-46fc-a55d-b9ecf0bec601; Winther L, Guardabassi L, Baptiste KE, Friis C. Antimicrobial disposition in pulmonary epithelial lining fluid of horses. Part I. Sulfadiazine and trimethoprim. J Vet Pharmacol Ther. 2011;34(3):277-284. doi:10.1111/j.1365-2885.2010.01229.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1223 (2026-08-01).
Sample dosing (2 of 25 cited rules)
A dog/cat sample is shown here. Cited dosing for all 13 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
Hillier A, Lloyd DH, Weese JS, et al. Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (antimicrobial guidelines working group of the international society for companion animal infectious diseases). Vet Dermatol. 2014;25(3):163-e43. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1222 (2026-08-01).
Weese JS, Blondeau J, Boothe D, et al. International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. Vet J. 2019;247:8-25. doi:10.1016/j.tvjl.2019.02.008 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1223 (2026-08-01).
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Gibbons PM, Klaphake E, Carpenter JW. Reptiles. In: Carpenter JW, ed. Exotic Animal Formulary. 4th ed. St. Louis: Elsevier; 2013:83-182. — Verified against Mader's Reptile and Amphibian Medicine and Surgery, 3rd Ed, p.1404 (2026-08-01).
· Hayes P. Diseases of chinchillas. In: Kirk's Current Veterinary Therapy: XIII Small Animal Practice. WB Saunders; 2000:1152-1157. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1223 (2026-08-01).
· Hillier A, Lloyd DH, Weese JS, et al. Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (antimicrobial guidelines working group of the international society for companion animal infectious diseases). Vet Dermatol. 2014;25(3):163-e43. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1222 (2026-08-01).
· Hillyer EV, Brown SA. Ferrets. In: Birchard SJ, Sherding RG, eds. Saunders Manual of Small Animal Practice; WB Saunders, Philadelphia, PA; 1994:1317-1344. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.934 (2026-08-01).
· Hoefer HL. Hedgehogs. Vet Clin North Am Small Anim Pract. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.734 (2026-08-01).
· Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. / 130. Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.774 (2026-08-01).
· Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015.; Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.774 (2026-08-01).
· Plumb's Veterinary Drug Handbook, 9th Ed, Sulfa-/Trimethoprim, printed p.1195 (corpus p.1222), DOGS — 'Superficial bacterial folliculitis (extra-label): 15 - 30 mg/kg PO twice daily.31' and 'Complicated UTI: 15 - 30 mg/kg PO every 12 hours32'. Superscript 31 = Hillier A, Lloyd DH, Weese JS, et al. Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (ISCAID Antimicrobial Guidelines Working Group). Vet Dermatol. 2014;25(3):163-e43. Superscript 32 = Weese JS, Blondeau J, Boothe D, et al. ISCAID guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. Vet J. 2019;247:8-25.
· Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1223 (2026-08-01).
· Weese JS, Blondeau J, Boothe D, et al. International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. Vet J. 2019;247:8-25. doi:10.1016/j.tvjl.2019.02.008 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1222 (2026-08-01).