Pocket Pet · Oryctolagus cuniculus · typical adult weight 1.00–5.00 kg
Trimethoprim-Sulfamethoxazole is dosed at 15–30 mg/kg PO q12h in rabbits, per Plumb DC. Plumb's Veterinary Drug Handbook, 9th ed., Wiley Blackwell, Ames, IA; 2018. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.845 (2026-08-01).. Trimethoprim-Sulfamethoxazole is used in rabbits for Bacterial infections, coccidiosis, Bacterial infections when oral not feasible. Routes documented in rabbits: PO, SC. A typical adult rabbit weighs 1.00–5.00 kg. ExoticRx lists 2 cited dose rules for Trimethoprim-Sulfamethoxazole in rabbits, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Bactrim, TMS
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 15–30 mg/kg | q12h | 7-14 days | Bacterial infections, coccidiosis | Moderate | Plumb DC. Plumb's Veterinary Drug Handbook, 9th ed., Wiley Blackwell, Ames, IA; 2018. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.845 (2026-08-01). |
| SC | 15–30 mg/kg | q12h | 7-14 days | Bacterial infections when oral not feasible | Moderate | Carpenter's Exotic Animal Formulary, 6th Ed |
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These ranges are per kg. Enter your rabbit's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Sequential blockade of folate synthesis: sulfamethoxazole inhibits dihydropteroate synthase; trimethoprim inhibits dihydrofolate reductase.
May cause keratoconjunctivitis sicca (KCS) in dogs with prolonged use. Can cause bone marrow suppression. Avoid in animals with hepatic disease. Adequate hydration required.
Species-specific contraindications and adverse-reaction reports for rabbits may differ from canine / feline reference data — consult the primary citations listed with each rule.
Trimethoprim-Sulfamethoxazole dose ranges in rabbits, with cited source references: PO 15–30 mg/kg q12h; SC 15–30 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Trimethoprim-Sulfamethoxazole in rabbits: PO, SC.
Cited course lengths for Trimethoprim-Sulfamethoxazole in rabbits include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Trimethoprim-Sulfamethoxazole is indicated in rabbits for: Bacterial infections, coccidiosis, Bacterial infections when oral not feasible.
These are general warnings for Trimethoprim-Sulfamethoxazole across species; consult the rabbit dosing table above for species-specific guidance. May cause keratoconjunctivitis sicca (KCS) in dogs with prolonged use. Can cause bone marrow suppression. Avoid in animals with hepatic disease. Adequate hydration required.
Why a species-specific page? Trimethoprim-Sulfamethoxazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in rabbits — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.