Pocket Pet · Oryctolagus cuniculus · typical adult weight 1.00–5.00 kg
Trimethoprim-Sulfamethoxazole is dosed at 15–30 mg/kg PO q12h in rabbits, per Plumb DC. Plumb's Veterinary Drug Handbook, 9th ed., Wiley Blackwell, Ames, IA; 2018. — Carpenter's Exotic Animal Formulary 6th ed, Table 10.1 (Antimicrobial Agents Used in Rabbits.a). — EDITION NOTE 2026-08-06: this rule's Plumb's reference names the 9th edition, which is not held and was never consulted. The held copy is the 10th ed (2023). The Plumb's line was never confirmed against the held edition, so rely on it only as background; any other source named in this citation is unaffected. Trimethoprim-Sulfamethoxazole is used in rabbits for Bacterial infections, coccidiosis, Bacterial infections when oral not feasible. Routes documented in rabbits: PO, SC. A typical adult rabbit weighs 1.00–5.00 kg. ExoticRx lists 2 cited dose rules for Trimethoprim-Sulfamethoxazole in rabbits, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Bactrim, TMS
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 15–30 mg/kg | q12h | 7-14 days | Bacterial infections, coccidiosis |
| Plumb DC. Plumb's Veterinary Drug Handbook, 9th ed., Wiley Blackwell, Ames, IA; 2018. — Carpenter's Exotic Animal Formulary 6th ed, Table 10.1 (Antimicrobial Agents Used in Rabbits.a). — EDITION NOTE 2026-08-06: this rule's Plumb's reference names the 9th edition, which is not held and was never consulted. The held copy is the 10th ed (2023). The Plumb's line was never confirmed against the held edition, so rely on it only as background; any other source named in this citation is unaffected.Compilation only — we have not located an independent source that prints this figure. |
| SC | 15–30 mg/kg | q12h | 7-14 days | Bacterial infections when oral not feasible | Moderate | Carpenter's Exotic Animal Formulary, 6th Ed — Carpenter's Exotic Animal Formulary 6th ed, Table 10.1 (Antimicrobial Agents Used in Rabbits.a).Compilation only — we have not located an independent source that prints this figure. |
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These ranges are per kg. Enter your rabbit's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Sequential blockade of folate synthesis: sulfamethoxazole inhibits dihydropteroate synthase; trimethoprim inhibits dihydrofolate reductase.
May cause keratoconjunctivitis sicca (KCS) in dogs with prolonged use. Can cause bone marrow suppression. Avoid in animals with hepatic disease. Adequate hydration required.
Species-specific contraindications and adverse-reaction reports for rabbits may differ from canine / feline reference data — consult the primary citations listed with each rule.
Trimethoprim-Sulfamethoxazole dose ranges in rabbits, with cited source references: PO 15–30 mg/kg q12h; SC 15–30 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Trimethoprim-Sulfamethoxazole in rabbits: PO, SC.
Cited course lengths for Trimethoprim-Sulfamethoxazole in rabbits include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Trimethoprim-Sulfamethoxazole is indicated in rabbits for: Bacterial infections, coccidiosis, Bacterial infections when oral not feasible.
These are general warnings for Trimethoprim-Sulfamethoxazole across species; consult the rabbit dosing table above for species-specific guidance. May cause keratoconjunctivitis sicca (KCS) in dogs with prolonged use. Can cause bone marrow suppression. Avoid in animals with hepatic disease. Adequate hydration required.
Why a species-specific page? Trimethoprim-Sulfamethoxazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in rabbits — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.