ExoticRx · exoticrx.com/drugs/tripelennamine
US brand names:Pelamine, Re-Covr
Tripelennamine is dosed at 1 mg/kg PO q12h in dogs, per Papich, Saunders Handbook of Veterinary Drugs, 4th ed. (2016), Tripelennamine Citrate and Tripelennamine Hydrochloride, printed p.823 (corpus papich p.851). Verify against current literature before clinical use.
First-generation H1-antihistamine that competitively blocks histamine at H1 receptors, reducing histamine-mediated vasodilation, increased vascular permeability, and pruritus.
Sedation is common. Anticholinergic side effects (dry mouth, urinary retention). Used primarily in horses and cattle. Largely replaced by newer antihistamines in small animals.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1 mg/kg | q12h | Moderate | Papich, Saunders Handbook of Veterinary Drugs, 4th ed. (2016), Tripelennamine Citrate and Tripelennamine Hydrochloride, printed p.823 (corpus papich p.851) |
| Cat (Domestic) | PO | 1 mg/kg | q12h | Extrapolated | Papich, Saunders Handbook of Veterinary Drugs, 4th ed. (2016), Tripelennamine Citrate and Tripelennamine Hydrochloride, printed p.823 (corpus papich p.851) |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.