ExoticRx · exoticrx.com/drugs/tripelennamine
Pelamine, Re-Covr
First-generation H1-antihistamine that competitively blocks histamine at H1 receptors, reducing histamine-mediated vasodilation, increased vascular permeability, and pruritus.
Sedation is common. Anticholinergic side effects (dry mouth, urinary retention). Used primarily in horses and cattle. Largely replaced by newer antihistamines in small animals.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–2 mg/kg | q8-12h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database |
| Cat (Domestic) | PO | 1–2 mg/kg | q12h | Extrapolated | Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database |
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