Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Tris-EDTA Otic is used in dogs for Potentiation of otic antimicrobials. Routes documented in dogs: Otic. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Tris-EDTA Otic in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: TrizEDTA, T8 Solution
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| Otic | Pre-treatment disrupts bacterial biofilm and outer membrane | Fill ear canal 10-15 min before antimicrobial | Use before each antimicrobial application | Potentiation of otic antimicrobials | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1498 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
EDTA chelates divalent cations (calcium, magnesium) from bacterial cell walls, disrupting outer membrane integrity of gram-negative bacteria and potentiating antimicrobial activity.
Use as pre-treatment before otic antimicrobials for best effect. Allow 10-15 minutes contact time. Generally very well tolerated. Safe if tympanic membrane status is unknown.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Tris-EDTA Otic dose range in dogs, with cited source references: Otic Pre-treatment disrupts bacterial biofilm and outer membrane Fill ear canal 10-15 min before antimicrobial. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Tris-EDTA Otic in dogs: Otic.
Cited course lengths for Tris-EDTA Otic in dogs include: Use before each antimicrobial application. Duration depends on the indication — match it to the specific dose rule in the table above.
Tris-EDTA Otic is indicated in dogs for: Potentiation of otic antimicrobials.
These are general warnings for Tris-EDTA Otic across species; consult the dog dosing table above for species-specific guidance. Use as pre-treatment before otic antimicrobials for best effect. Allow 10-15 minutes contact time. Generally very well tolerated. Safe if tympanic membrane status is unknown.
Why a species-specific page? Tris-EDTA Otic pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.