ExoticRx · exoticrx.com/drugs/tris-edta-otic
US brand names:TrizEDTA, T8 Solution
EDTA chelates divalent cations (calcium, magnesium) from bacterial cell walls, disrupting outer membrane integrity of gram-negative bacteria and potentiating antimicrobial activity.
Use as pre-treatment before otic antimicrobials for best effect. Allow 10-15 minutes contact time. Generally very well tolerated. Safe if tympanic membrane status is unknown.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | Otic | Pre-treatment disrupts bacterial biofilm and outer membrane | Fill ear canal 10-15 min before antimicrobial | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1498 (2026-08-01). |
| Cat (Domestic) | Otic | Safe and well tolerated | Fill ear canal, massage, allow 10-15 min contact | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1498 (2026-08-01). |
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