What is Clotrimazole Otic used for?

Clotrimazole Otic is indicated for: Malassezia otitis, Malassezia/yeast otitis.

Which species have cited Clotrimazole Otic dosing data?

Clotrimazole Otic dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Is Clotrimazole Otic a controlled substance?

Clotrimazole Otic is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

What are the side effects of Clotrimazole Otic?

Reported side effects, adverse reactions, and contraindications for Clotrimazole Otic: For external ear canal only. Do not use with ruptured tympanic membrane. Part of combination products. May cause mild local irritation.

Clotrimazole Otic

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Otic

Routes

Otic

Indications

Malassezia otitisMalassezia/yeast otitis

Mechanism of Action

Inhibits ergosterol synthesis in fungal cell membranes. Effective against Malassezia and Candida in ear canal.

Side effects & warnings

For external ear canal only. Do not use with ruptured tympanic membrane. Part of combination products. May cause mild local irritation.

Species with Clotrimazole Otic dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugs All Dog (Domestic) drugs

Evidence levels across 2 dose rules

Strong×1Moderate×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published sources

· Plumb's Veterinary Drug Handbook, 10th ed (held), Clotrimazole otic use - see BOTH "Antifungal Agents, Otic" printed p.1471-1472 (corpus PDF p.1498-1499), which lists Clotrimazole 1% solution labeled for dogs and cats at 1 to 2 times daily, AND "Corticosteroid/Antimicrobial Agents, Otic" printed p.1478-1479, which carries the Otomax-type gentamicin-clotrimazole-betamethasone products at 2 to 3 times daily. [CORRECTED - printed p.1434 is Clotrimazole Topical, which routes otic use away from itself.]
· Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1499 (2026-08-01). — Plumb's 10th ed (held) printed p.1434, Clotrimazole, Topical monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	Otic	See the cited source for the printed regimen	q12h	Strong	Plumb's Veterinary Drug Handbook, 10th ed (held), Clotrimazole otic use - see BOTH "Antifungal Agents, Otic" printed p.1471-1472 (corpus PDF p.1498-1499), which lists Clotrimazole 1% solution labeled for dogs and cats at 1 to 2 times daily, AND "Corticosteroid/Antimicrobial Agents, Otic" printed p.1478-1479, which carries the Otomax-type gentamicin-clotrimazole-betamethasone products at 2 to 3 times daily. [CORRECTED - printed p.1434 is Clotrimazole Topical, which routes otic use away from itself.]
Cat (Domestic)	Otic	See the cited source for the printed regimen	q12h	Moderate	Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1499 (2026-08-01). — Plumb's 10th ed (held) printed p.1434, Clotrimazole, Topical monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207,

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