ExoticRx · exoticrx.com/drugs/clotrimazole-topical
US brand names:Lotrimin, Mycelex
Imidazole antifungal that inhibits ergosterol synthesis by blocking lanosterol 14-alpha demethylase (CYP51), disrupting fungal cell membrane integrity.
For localized dermatophytosis and Malassezia dermatitis. Apply twice daily. Low systemic absorption. May cause local irritation. Systemic therapy needed for widespread infection.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | Topical | Monitor for clinical improvement at 2 weeks | Apply to affected area q12h | Strong | Gupta AK, et al: Antifungal agents: An overview: Part II. J Am Acad Dermatol 30:911, 1994. / 40. Grooters AM, Taboada J: Update on antifungal therapy. Vet Clin North Am Small Anim Pract 33:749-758, 2003. — Muller & Kirk's Small Animal Dermatology, 7th Ed, p.225Compilation only — we have not located an independent source that prints this figure. |
| Cat (Domestic) | Topical | Cream formulation preferred over solution | Apply to affected area q12h | Moderate | Gupta AK, et al: Antifungal agents: An overview: Part II. J Am Acad Dermatol 30:911, 1994. / 40. Grooters AM, Taboada J: Update on antifungal therapy. Vet Clin North Am Small Anim Pract 33:749-758, 2003. — Muller & Kirk's Small Animal Dermatology, 7th Ed, p.225Compilation only — we have not located an independent source that prints this figure. |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.