ExoticRx · exoticrx.com/drugs/valproic-acid
US brand names:Depakene, Depakote(divalproex)
Valproic Acid is dosed at 25–60 mg/kg PO q8h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Increases GABA levels by inhibiting GABA transaminase and blocking voltage-gated sodium channels. Broad-spectrum anticonvulsant.
Rapidly metabolized in dogs (very short half-life, impractical for chronic use). Hepatotoxic. Teratogenic. May cause thrombocytopenia. Limited use in veterinary medicine.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 25–60 mg/kg | q8h | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.