ExoticRx · exoticrx.com/drugs/valproic-acid
US brand names:Depakene, Depakote(divalproex)
Increases GABA levels by inhibiting GABA transaminase and blocking voltage-gated sodium channels. Broad-spectrum anticonvulsant.
Rapidly metabolized in dogs (very short half-life, impractical for chronic use). Hepatotoxic. Teratogenic. May cause thrombocytopenia. Limited use in veterinary medicine.
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