Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Acetylcysteine Ophthalmic is used in dogs for Melting corneal ulcer (collagenase inhibition). Routes documented in dogs: Ophthalmic. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Acetylcysteine Ophthalmic in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Mucomyst Ophthalmic Compounded
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| Ophthalmic | Must be compounded (5-10%) | 1 drop affected eye q1-2h initially, then q4-6h | Continue until melting stops and epithelial healing begins | Melting corneal ulcer (collagenase inhibition) | Strong | Ollivier, F.J., Gilger, B.C., Barrie, K.P., et al. (2007) Proteinases of the cornea and preocular tear film. Veterinary Ophthalmology, 10, 199-206. — Verified against Veterinary Ophthalmology (Gelatt), 6th Ed, p.1145 (2026-08-01). — SOURCE EDITION: Veterinary Ophthalmology — ISBN 9781119441830, https://openlibrary.org/isbn/9781119441830 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (%) | Route | Source | As printed |
|---|---|---|---|
| 2 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.36 | • Eye solution: 2% solution topically q2h. |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 70 | IM | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.19 | n over 15-20 min, followed by further slow infusions of 70 mg/kg (similarly diluted) every 6 hours for at least 7 doses, depending on dose of par |
| 140–280 |
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Thiol compound that inhibits collagenase (matrix metalloproteinases) in melting corneal ulcers. Breaks disulfide bonds in mucus, also reducing mucus viscosity on the corneal surface.
Must be compounded for ophthalmic use. Essential for melting/keratomalacia ulcers. Apply every 1-2 hours initially. Stinging on application. Refrigerate compounded solutions. Short shelf life.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Acetylcysteine Ophthalmic dose range in dogs, with cited source references: Ophthalmic Must be compounded (5-10%) 1 drop affected eye q1-2h initially, then q4-6h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Acetylcysteine Ophthalmic in dogs: Ophthalmic.
Cited course lengths for Acetylcysteine Ophthalmic in dogs include: Continue until melting stops and epithelial healing begins. Duration depends on the indication — match it to the specific dose rule in the table above.
Acetylcysteine Ophthalmic is indicated in dogs for: Melting corneal ulcer (collagenase inhibition).
These are general warnings for Acetylcysteine Ophthalmic across species; consult the dog dosing table above for species-specific guidance. Must be compounded for ophthalmic use. Essential for melting/keratomalacia ulcers. Apply every 1-2 hours initially. Stinging on application. Refrigerate compounded solutions. Short shelf life.
Why a species-specific page? Acetylcysteine Ophthalmic pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| IV |
| BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.19 |
| riate, i.e. presented within 2 hours of ingestion) give 140-280 mg/kg diluted to a 5% solution using 5% dextrose by slow i.v. infusion over 15-20 min, |
| 70 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.36 | • Antidote: 140 mg/kg (loading dose), then 70 mg/kg q4h IV or PO for 5 doses. |
| 17 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.36 | • To prevent contrast-medium nephropathy: 17 mg/kg IV bolus, followed by |
| 17 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.36 | 17 mg/kg every 12 hours for 48 hours. |
| 50 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.36 | • Constant-rate infusions have been used to treat oxidative stress (50 mg/kg |
| 140 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.36 | • Antidote: 140 mg/kg (loading dose), then 70 mg/kg q4h IV or PO for 5 doses. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.