Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Brimonidine Ophthalmic is used in dogs for Glaucoma adjunct. Routes documented in dogs: TOPICAL (ophthalmic). A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Brimonidine Ophthalmic in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Alphagan
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| TOPICAL (ophthalmic) | Use cautiously in small dogs — systemic alpha-2 effects possible | q8-12h | Long-term | Glaucoma adjunct | Weak | Gelatt KN, MacKay EO. Effect of single and multiple doses of 0.2% brimonidine tartrate in the glaucomatous beagle. Vet Ophthalmol. 2002;5(4):253-262. doi:10.1046/j.1463-5224.2002.00222.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1377 (2026-08-01). |
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Alpha-2 adrenergic agonist that decreases aqueous humor production and increases uveoscleral outflow. Also neuroprotective to retinal ganglion cells.
TOXIC in cats and small dogs (systemic alpha-2 effects: sedation, bradycardia, hypotension). Avoid in cats. Use with caution in small dogs. Monitor for CNS depression.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Brimonidine Ophthalmic dose range in dogs, with cited source references: TOPICAL (ophthalmic) Use cautiously in small dogs — systemic alpha-2 effects possible q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Brimonidine Ophthalmic in dogs: TOPICAL (ophthalmic).
Cited course lengths for Brimonidine Ophthalmic in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Brimonidine Ophthalmic is indicated in dogs for: Glaucoma adjunct.
These are general warnings for Brimonidine Ophthalmic across species; consult the dog dosing table above for species-specific guidance. TOXIC in cats and small dogs (systemic alpha-2 effects: sedation, bradycardia, hypotension). Avoid in cats. Use with caution in small dogs. Monitor for CNS depression.
Why a species-specific page? Brimonidine Ophthalmic pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.