ExoticRx · exoticrx.com/drugs/ambrisentan
Letairis
Selective endothelin type A (ETA) receptor antagonist that blocks endothelin-1 mediated vasoconstriction and smooth muscle proliferation in pulmonary vasculature.
Hepatotoxicity risk — monitor liver enzymes. Peripheral edema. Teratogenic. Used for pulmonary hypertension in dogs when sildenafil alone is insufficient.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.25–0.5 mg/kg | q24h | Weak | JVIM 2019; Veterinary Cardiology Literature |
| Cat (Domestic) | PO | 0.25–0.5 mg/kg | q24h | Extrapolated | JVIM 2019; Veterinary Cardiology Literature |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.