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Ambrisentan

Letairis

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Respiratory

Routes

PO

Indications

Pulmonary hypertension

Mechanism of Action

Selective endothelin type A (ETA) receptor antagonist that blocks endothelin-1 mediated vasoconstriction and smooth muscle proliferation in pulmonary vasculature.

Side effects & warnings

Hepatotoxicity risk — monitor liver enzymes. Peripheral edema. Teratogenic. Used for pulmonary hypertension in dogs when sildenafil alone is insufficient.

Species with Ambrisentan dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs

Evidence levels across 2 dose rules

Weak×1Extrapolated×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · JVIM 2019; Veterinary Cardiology Literature

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO0.25–0.5 mg/kgq24hWeakJVIM 2019; Veterinary Cardiology Literature
Cat (Domestic)PO0.25–0.5 mg/kgq24hExtrapolatedJVIM 2019; Veterinary Cardiology Literature

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