ExoticRx · exoticrx.com/drugs/ambrisentan
US brand names:Letairis
Ambrisentan is dosed at 0.25–0.5 mg/kg PO q24h in dogs, per JVIM 2019; Veterinary Cardiology Literature. Verify against current literature before clinical use.
Selective endothelin type A (ETA) receptor antagonist that blocks endothelin-1 mediated vasoconstriction and smooth muscle proliferation in pulmonary vasculature.
Hepatotoxicity risk — monitor liver enzymes. Peripheral edema. Teratogenic. Used for pulmonary hypertension in dogs when sildenafil alone is insufficient.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.25–0.5 mg/kg | q24h | Weak | JVIM 2019; Veterinary Cardiology Literature |
| Cat (Domestic) | PO | 0.25–0.5 mg/kg | q24h | Extrapolated | JVIM 2019; Veterinary Cardiology Literature |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.