Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.
Aminophylline is dosed at 50 mg/kg PO q12h in guinea pigs, per Carpenter's Exotic Animal Formulary, 6th Ed — Carpenter's Exotic Animal Formulary 6th ed, Table 9.7 (Miscellaneous Agents Used in Rodents). Verify against current literature before clinical use.
Phosphodiesterase inhibitor and adenosine receptor antagonist. Relaxes bronchial smooth muscle, stimulates respiratory drive, and has mild diuretic effect.
Side effects & warnings
Narrow therapeutic index. Monitor for tachycardia, GI upset, CNS stimulation, and seizures. Avoid concurrent fluoroquinolones (decreased metabolism). IV administration must be slow.
Species with Aminophylline dosing data (18 dose rules)
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Sample dosing (2 of 18 cited rules)
A dog/cat sample is shown here. Cited dosing for all 15 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
Plumb's Veterinary Drug Handbook, 10th ed (2023) — Plumb's 10th ed printed p.53, Aminophylline monograph spanning p.53-55. — Plumb's 10th ed printed p.54, Aminophylline monograph.Compilation only — we have not located an independent source that prints this figure.
Plumb's Veterinary Drug Handbook, 10th ed (2023) — Plumb's 10th ed printed p.53, Aminophylline monograph spanning p.53-55. — Plumb's 10th ed printed p.54, Aminophylline monograph.Compilation only — we have not located an independent source that prints this figure.
· 529. Lichtenberger M. Treatment of respiratory inhalant toxins in 4 psittacine birds. Proc Annu Conf Assoc Avian Vet; 2003:39-43. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.489 — Carpenter's Exotic Animal Formulary 6th ed, Table 5.18 (Miscellaneous Agents Used in Birds).
· 63. Carpenter JW, Klaphake E, Gibbons PM, et al. Reptile formulary. In: Divers SJ, Stahl SJ, eds. Mader's Reptile and Amphibian Medicine and Surgery, 3rd ed., Elsevier, St. Louis, MO; 2019:1191-1211. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.271 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.11 (Miscellaneous Agents Used in Reptiles).
· 89. Frye FL. Reptile Clinician's Handbook. Malabar, FL: Krieger Publishing; 1994. — Source: Mader's Reptile and Amphibian Medicine and Surgery, 3rd Ed, p.1419
· BSAVA Small Animal Formulary, 10th ed, Part A (Canine and Feline), Aminophylline, printed p.20
· Carpenter JW, Klaphake E, Gibbons PM, et al. Reptile formulary. In: Divers SJ, Stahl SJ, eds. Mader's Reptile and Amphibian Medicine and Surgery, 3rd ed., Elsevier, St. Louis, MO; 2019:1191-1211. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.271 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.11 (Miscellaneous Agents Used in Reptiles).
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