ExoticRx · exoticrx.com/drugs/aminocaproic-acid-oral
US brand names:Amicar
Aminocaproic Acid Oral is dosed at 500 mg per dog (NOT mg/kg) PO q8h in dogs, per (Plumb's Aminocaproic Acid ref 3, cited for the 20/50/100 mg/kg PO canine data on p.78-79) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.79 (2026-08-01). — Plumb's 10th ed (held) printed p.51, Aminocaproic Acid monograph spanning p.51-52; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 BASIS CORRECTED 2026-08-13: served as mg/kg, which the calculator multiplies by body weight. Plumb's Veterinary Drug Handbook 10th ed, corpus p.40, verbatim: "Used in conjunction with aminocaproic acid at a dosage of 500 mg per dog (NOT mg/kg) PO every 8 hours indefinitely." As a per-kg figure the served range delivered roughly 75-200 mg to a 5 kg dog and 750-2000 mg to a 50 kg dog against a printed flat 500 mg. Read from the page 2026-08-13.. Verify against current literature before clinical use.
Competitively inhibits plasminogen activation, preventing fibrinolysis. Stabilizes existing clots by blocking conversion of plasminogen to plasmin.
May cause GI upset. Contraindicated with DIC. Monitor for thrombosis. Used in dogs for degenerative myelopathy (off-label) and bleeding disorders.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 500 mg per dog (NOT mg/kg) | q8h | Weak | (Plumb's Aminocaproic Acid ref 3, cited for the 20/50/100 mg/kg PO canine data on p.78-79) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.79 (2026-08-01). — Plumb's 10th ed (held) printed p.51, Aminocaproic Acid monograph spanning p.51-52; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 BASIS CORRECTED 2026-08-13: served as mg/kg, which the calculator multiplies by body weight. Plumb's Veterinary Drug Handbook 10th ed, corpus p.40, verbatim: "Used in conjunction with aminocaproic acid at a dosage of 500 mg per dog (NOT mg/kg) PO every 8 hours indefinitely." As a per-kg figure the served range delivered roughly 75-200 mg to a 5 kg dog and 750-2000 mg to a 50 kg dog against a printed flat 500 mg. Read from the page 2026-08-13. |
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