ExoticRx · exoticrx.com/drugs/aminocaproic-acid-oral
US brand names:Amicar
Aminocaproic Acid Oral is dosed at 15–40 mg/kg PO q8h in dogs, per (Plumb's Aminocaproic Acid ref 3, cited for the 20/50/100 mg/kg PO canine data on p.78-79) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.79 (2026-08-01).. Verify against current literature before clinical use.
Competitively inhibits plasminogen activation, preventing fibrinolysis. Stabilizes existing clots by blocking conversion of plasminogen to plasmin.
May cause GI upset. Contraindicated with DIC. Monitor for thrombosis. Used in dogs for degenerative myelopathy (off-label) and bleeding disorders.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 15–40 mg/kg | q8h | Weak | (Plumb's Aminocaproic Acid ref 3, cited for the 20/50/100 mg/kg PO canine data on p.78-79) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.79 (2026-08-01). |
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