ExoticRx · exoticrx.com/drugs/aminocaproic-acid
US brand names:Amicar
Aminocaproic Acid is dosed at 500 mg per dog (NOT mg/kg) PO q8h in dogs, per Marin LM, Iazbik MC, Zaldivar-Lopez S, et al. Retrospective evaluation of the effectiveness of epsilon aminocaproic acid for the prevention of postamputation bleeding in retired racing Greyhounds with appendicular bone tumors: 46 cases (2003-2008). J Vet Emerg Crit Care (San Antonio). 2012;22(3):332-340. doi:10.1111/j.1476-4431.2012.00735.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.79 (2026-08-01). — Plumb's 10th ed (held) printed p.51, Aminocaproic Acid monograph spanning p.51-52; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 BASIS CORRECTED 2026-08-13: served as mg/kg, which the calculator multiplies by body weight. Plumb's Veterinary Drug Handbook 10th ed, corpus p.40, verbatim: "Used in conjunction with aminocaproic acid at a dosage of 500 mg per dog (NOT mg/kg) PO every 8 hours indefinitely." As a per-kg figure the served range delivered roughly 75-200 mg to a 5 kg dog and 750-2000 mg to a 50 kg dog against a printed flat 500 mg. Read from the page 2026-08-13.. Verify against current literature before clinical use.
Inhibits fibrinolysis by blocking plasminogen activator and, to a lesser extent, antiplasmin activity. Stabilizes clots.
Used for degenerative myelopathy (German Shepherds — controversial efficacy), post-surgical hemorrhage. Thrombosis risk. GI upset. Monitor for signs of thromboembolism.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 500 mg per dog (NOT mg/kg) | q8h | Weak | Marin LM, Iazbik MC, Zaldivar-Lopez S, et al. Retrospective evaluation of the effectiveness of epsilon aminocaproic acid for the prevention of postamputation bleeding in retired racing Greyhounds with appendicular bone tumors: 46 cases (2003-2008). J Vet Emerg Crit Care (San Antonio). 2012;22(3):332-340. doi:10.1111/j.1476-4431.2012.00735.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.79 (2026-08-01). — Plumb's 10th ed (held) printed p.51, Aminocaproic Acid monograph spanning p.51-52; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 BASIS CORRECTED 2026-08-13: served as mg/kg, which the calculator multiplies by body weight. Plumb's Veterinary Drug Handbook 10th ed, corpus p.40, verbatim: "Used in conjunction with aminocaproic acid at a dosage of 500 mg per dog (NOT mg/kg) PO every 8 hours indefinitely." As a per-kg figure the served range delivered roughly 75-200 mg to a 5 kg dog and 750-2000 mg to a 50 kg dog against a printed flat 500 mg. Read from the page 2026-08-13. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.