ExoticRx · exoticrx.com/drugs/bedaquiline
US brand names:Sirturo
Bedaquiline is dosed at 5–10 mg/kg PO q24h x 2wks, then q48h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Inhibits mycobacterial ATP synthase proton pump, disrupting energy production. Novel target specific to mycobacteria.
QTc prolongation. Hepatotoxicity. Very long half-life (~5 months). Reserved for MDR-TB. No veterinary data.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.