Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Clodronate is used in dog for Bone pain, osteolytic lesions, pathological bone resorption. Routes documented in dog: SC. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Clodronate in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Osphos
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| SC | 20–25 mg/kg | Single dose or monthly | Single injection; may repeat monthly based on response | Bone pain, osteolytic lesions, pathological bone resorption | Weak | JAVMA; FDA openFDA Adverse Event Database |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits osteoclast-mediated bone resorption by being incorporated into ATP analogs that are cytotoxic to osteoclasts. Reduces pathological bone remodeling and associated pain.
FDA-approved for horses with navicular syndrome. Renal toxicity possible at high doses. May cause GI signs, colic, or transient discomfort post-injection. Limited small animal data.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Clodronate pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.