Cat · Felis catus · typical adult weight 2.50–7.00 kg
Cloxacillin is dosed at 20–40 mg/kg PO q8h in cats, per Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.210 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.210' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.182; verified by finding the drug named there. If you are holding the book, turn to p.182. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855. Cloxacillin is used in cats for Staphylococcal infections. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Cloxacillin in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Orbenin, Dry-Clox
Contraindicated in Rabbit, Guinea Pig, Chinchilla, Hamster, Degu
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 20–40 mg/kg | q8h | 7-14 days | Staphylococcal infections | Extrapolated | Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.210 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.210' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.182; verified by finding the drug named there. If you are holding the book, turn to p.182. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 20–40 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.210 | • 20-40 mg/kg q8h PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Inhibits bacterial cell wall synthesis by binding to PBPs. Resistant to staphylococcal penicillinase, providing targeted activity against penicillinase-producing Staphylococcus spp.
Cross-allergenicity with other beta-lactams. GI upset common with oral administration. Primarily used for staphylococcal mastitis in cattle.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Cloxacillin dose range in cats, with cited source references: PO 20–40 mg/kg q8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Cloxacillin in cats: PO.
Cited course lengths for Cloxacillin in cats include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Cloxacillin is indicated in cats for: Staphylococcal infections.
These are general warnings for Cloxacillin across species; consult the cat dosing table above for species-specific guidance. Cross-allergenicity with other beta-lactams. GI upset common with oral administration. Primarily used for staphylococcal mastitis in cattle.
Why a species-specific page? Cloxacillin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.