ExoticRx · exoticrx.com/drugs/cloxacillin
Orbenin, Dry-Clox
Inhibits bacterial cell wall synthesis by binding to PBPs. Resistant to staphylococcal penicillinase, providing targeted activity against penicillinase-producing Staphylococcus spp.
Cross-allergenicity with other beta-lactams. GI upset common with oral administration. Primarily used for staphylococcal mastitis in cattle.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 20–40 mg/kg | q8h | Extrapolated | Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database |
| Cat (Domestic) | PO | 20–40 mg/kg | q8h | Extrapolated | Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database |
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