Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Cloxacillin is used in dog for Staphylococcal skin and soft tissue infections. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Cloxacillin in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Orbenin, Dry-Clox
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 20–40 mg/kg | q8h | 7-14 days | Staphylococcal skin and soft tissue infections | Extrapolated | Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits bacterial cell wall synthesis by binding to PBPs. Resistant to staphylococcal penicillinase, providing targeted activity against penicillinase-producing Staphylococcus spp.
Cross-allergenicity with other beta-lactams. GI upset common with oral administration. Primarily used for staphylococcal mastitis in cattle.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Cloxacillin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.