ExoticRx · exoticrx.com/drugs/colistimethate-sodium-colistin-inhalation
US brand names:Coly-Mycin M, Polymyxin E, Colistin
Colistimethate Sodium (Colistin Inhalation) is dosed at 2–4 mg/kg IV q12h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Interacts with LPS in gram-negative outer membranes causing membrane disruption and cell death. Bactericidal.
Nephrotoxic and neurotoxic. Bronchospasm with inhalation. Last-resort agent for MDR gram-negative infections.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.