ExoticRx · exoticrx.com/drugs/dapsone
US brand names:Aczone
Dapsone is dosed at 1 mg/kg PO q8h initially, then q12h maintenance in dogs, per Miller WH, Small Animal Dermatology, 7th Ed. Verify against current literature before clinical use.
Inhibits neutrophil myeloperoxidase and chemotaxis. Suppresses the alternative complement pathway. Also has antibacterial activity against Mycobacterium leprae.
Methemoglobinemia and hemolytic anemia risk, especially in cats. Monitor CBC regularly. Hepatotoxic. Screen for G6PD deficiency when possible.
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1 mg/kg | q8h initially, then q12h maintenance | Moderate | Miller WH, Small Animal Dermatology, 7th Ed |
| Dog (Domestic) | PO | 1 mg/kg | q8h | Weak | Parker W, Foster R: Cutaneous vasculitis in five Jack Russell terriers. Vet Dermatol 7:109, 1996. doi:10.1111/j.1365-3164.1996.tb00235.x; Fadok V, Barrie J: Sulfasalazine-responsive vasculitis in the dog: a case report. J Am Anim Hosp Assoc 20:161, 1984. — Verified against Muller & Kirk's Small Animal Dermatology, 7th Ed, p.499 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.