ExoticRx · exoticrx.com/drugs/dapsone
US brand names:Aczone
Dapsone is dosed at 1 mg/kg PO q8h in dogs, per Parker W, Foster R: Cutaneous vasculitis in five Jack Russell terriers. Vet Dermatol 7:109, 1996. doi:10.1111/j.1365-3164.1996.tb00235.x; Fadok V, Barrie J: Sulfasalazine-responsive vasculitis in the dog: a case report. J Am Anim Hosp Assoc 20:161, 1984. — Verified against Muller & Kirk's Small Animal Dermatology, 7th Ed, p.499 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.499' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.487; verified by finding the drug named there. If you are holding the book, turn to p.487. — SOURCE EDITION: Muller & Kirk's Small Animal Dermatology — ISBN 9781416000280, https://openlibrary.org/isbn/9781416000280. Verify against current literature before clinical use.
Inhibits neutrophil myeloperoxidase and chemotaxis. Suppresses the alternative complement pathway. Also has antibacterial activity against Mycobacterium leprae.
Methemoglobinemia and hemolytic anemia risk, especially in cats. Monitor CBC regularly. Hepatotoxic. Screen for G6PD deficiency when possible.
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1 mg/kg | q8h | Weak | Parker W, Foster R: Cutaneous vasculitis in five Jack Russell terriers. Vet Dermatol 7:109, 1996. doi:10.1111/j.1365-3164.1996.tb00235.x; Fadok V, Barrie J: Sulfasalazine-responsive vasculitis in the dog: a case report. J Am Anim Hosp Assoc 20:161, 1984. — Verified against Muller & Kirk's Small Animal Dermatology, 7th Ed, p.499 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.499' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.487; verified by finding the drug named there. If you are holding the book, turn to p.487. — SOURCE EDITION: Muller & Kirk's Small Animal Dermatology — ISBN 9781416000280, https://openlibrary.org/isbn/9781416000280 |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.