Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Dapsone is used in dog for Immune-mediated skin disease (pemphigus, vasculitis), Sterile neutrophilic dermatosis (Sweet syndrome). Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Dapsone in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Aczone
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1 mg/kg | q8h initially, then q12h maintenance | Chronic use; monitor CBC biweekly for first 3 months | Immune-mediated skin disease (pemphigus, vasculitis) | Moderate | Miller WH, Small Animal Dermatology, 7th Ed |
| PO | 1 mg/kg | q8h | Until remission, then taper | Sterile neutrophilic dermatosis (Sweet syndrome) | Weak | Miller WH, Small Animal Dermatology, 7th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits neutrophil myeloperoxidase and chemotaxis. Suppresses the alternative complement pathway. Also has antibacterial activity against Mycobacterium leprae.
Methemoglobinemia and hemolytic anemia risk, especially in cats. Monitor CBC regularly. Hepatotoxic. Screen for G6PD deficiency when possible.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Dapsone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.