Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Dapsone is dosed at 1 mg/kg PO q8h initially, then q12h maintenance in dogs, per Miller WH, Small Animal Dermatology, 7th Ed. Dapsone is used in dogs for Immune-mediated skin disease (pemphigus, vasculitis), Sterile neutrophilic dermatosis (Sweet syndrome). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Dapsone in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Aczone
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1 mg/kg | q8h initially, then q12h maintenance | Chronic use; monitor CBC biweekly for first 3 months | Immune-mediated skin disease (pemphigus, vasculitis) | Moderate | Miller WH, Small Animal Dermatology, 7th Ed |
| PO | 1 mg/kg | q8h | Until remission, then taper | Sterile neutrophilic dermatosis (Sweet syndrome) | Weak | Parker W, Foster R: Cutaneous vasculitis in five Jack Russell terriers. Vet Dermatol 7:109, 1996. doi:10.1111/j.1365-3164.1996.tb00235.x; Fadok V, Barrie J: Sulfasalazine-responsive vasculitis in the dog: a case report. J Am Anim Hosp Assoc 20:161, 1984. — Verified against Muller & Kirk's Small Animal Dermatology, 7th Ed, p.499 (2026-08-01). |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits neutrophil myeloperoxidase and chemotaxis. Suppresses the alternative complement pathway. Also has antibacterial activity against Mycobacterium leprae.
Methemoglobinemia and hemolytic anemia risk, especially in cats. Monitor CBC regularly. Hepatotoxic. Screen for G6PD deficiency when possible.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Dapsone dose ranges in dogs, with cited source references: PO 1 mg/kg q8h initially, then q12h maintenance; PO 1 mg/kg q8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Dapsone in dogs: PO.
Cited course lengths for Dapsone in dogs include: Chronic use; monitor CBC biweekly for first 3 months; Until remission, then taper. Duration depends on the indication — match it to the specific dose rule in the table above.
Dapsone is indicated in dogs for: Immune-mediated skin disease (pemphigus, vasculitis), Sterile neutrophilic dermatosis (Sweet syndrome).
These are general warnings for Dapsone across species; consult the dog dosing table above for species-specific guidance. Methemoglobinemia and hemolytic anemia risk, especially in cats. Monitor CBC regularly. Hepatotoxic. Screen for G6PD deficiency when possible.
Why a species-specific page? Dapsone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.